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Antiinflammatory and vasoprotective activities of polysaccharides isolated from fruit bodies of higher Fungi P.1. polysaccharides from Trametes gibbosa (Pers.: Fr)Fr. (Polyporaceae)
Author(s) -
Czarnecki Ryszard,
Grzybek Jan
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090209
Subject(s) - polysaccharide , polyporaceae , vascular permeability , exudate , carrageenan , chemistry , biology , basidiomycota , biochemistry , botany , endocrinology
Polysaccharide fractions TG‐1 and TG‐2 were isolated from the fruit bodies of Trametes gibbosa (Pers.: Fr.) Fr.(Polyporaceae). Both fractions are glucans with trace amounts of other sugars. The polysaccharide fractions administered to rats intravenously, strongly inhibited vessel permeability in the rat pleural exudate model, induced by carragenan, but did not influence its density. Both polysaccharide fractions decreased considerably the total protein level in the pleural effusion. Fractions TG‐1 and TG‐2 antagonized effectively the inflammation mediator complex induced by carragenan and they neutralized the pharmacological effects with respect to small vessel permeability. At the same time they increased the number of neutrophils and eosinophils and decreased the number of lymphocytes in the peripheral blood. The pharmacological activity of polysaccharide fractions TG‐1 and TG‐2 confirms their function as potential factors responsible for the stabilization of a wall vessel, especially in pathological conditions leading to endothelial damage.