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Ethanol extract of Crocus sativus L. Antagonizes the inhibitory action of ethanol on hippocampal long‐term potentiation in vivo
Author(s) -
Sugiura Minoru,
Saito Hiroshi,
Abe Kazuho,
Shoyama Yukihiro
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090204
Subject(s) - long term potentiation , dentate gyrus , tetanic stimulation , pharmacology , ltp induction , hippocampus , stimulation , hippocampal formation , ethanol , synaptic plasticity , chemistry , medicine , endocrinology , biochemistry , receptor
The effect of an ethanol extract of Crocus sativus L. (CSE) on the long‐term potentiation (LTP) of the evoked potential in the dentate gyrus of the hippocampus was investigated using anaesthetized rats. CSE (250 mg/kg, p.o.) alone did not affect the generation of LTP by application of subthreshold or suprathreshold tetanic stimulation (20 or 30 pulses at 60 Hz). Oral administration of ethanol (10–30%, 10 mL/kg) blocked the LTP induced by tetanic stimulation of 30 pulses at 60 Hz, but the LTP‐blocking effect of ethanol was significantly attenuated by pre‐administration of CSE (125 and 250 mg/kg, p.o.). The blockade of LTP induction by intravenously injected ethanol (30%, 2 mL/kg) was also antagonized by administration of CSE at doses of 125 and 250 mg/kg (p.o.). Oral administration of CSE antagonized also the LTP‐blocking effect of ethanol directly injected into the brain, although it required a higher dose (500 mg/kg, p.o.). These results suggest that oral administration of CSE exerts an antagonistic effect on ethanol‐induced impairment of hippocampal synaptic plasticity, which is possibly mediated by both direct action on the central nervous system and peripheral action.