In vitro  antiplasmodial effects of diospyrin, a plant‐derived naphthoquinoid, and a novel series of derivatives | Zendy

Hazra Banasri | Zendy; Ghosh Rina | Zendy; Banerjee Amalendu | Zendy; Kirby Geoffrey C. | Zendy; Warhurst David C. | Zendy; Phillipson J. David | Zendy

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In vitro antiplasmodial effects of diospyrin, a plant‐derived naphthoquinoid, and a novel series of derivatives

Author(s) -

Hazra Banasri,

Ghosh Rina,

Banerjee Amalendu,

Kirby Geoffrey C.,

Warhurst David C.,

Phillipson J. David

Publication year - 1995

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650090118

Subject(s) - in vitro , antiparasitic , plasmodium falciparum , leishmania donovani , natural product , pharmacology , pharmacognosy , protozoa , biology , ehrlich ascites carcinoma , chemistry , stereochemistry , traditional medicine , biological activity , leishmaniasis , biochemistry , medicine , microbiology and biotechnology , malaria , immunology , visceral leishmaniasis , pathology

Synthesis of derivatives of diospyrin, a natural product, has led to the modification of its tumour‐inhibitory effect, in vitro , towards Ehrlich ascites carcinoma and antiparasitic activity against Leishmania donovani in vitro . The present study shows that two of these novel hydroquinoid analogues derived from diospyrin also show enhanced inhibitory effects against Plasmodium falciparum, in vitro , and may be a useful model for the development of novel antimalarial drugs.

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