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In vitro antiplasmodial effects of diospyrin, a plant‐derived naphthoquinoid, and a novel series of derivatives
Author(s) -
Hazra Banasri,
Ghosh Rina,
Banerjee Amalendu,
Kirby Geoffrey C.,
Warhurst David C.,
Phillipson J. David
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090118
Subject(s) - in vitro , antiparasitic , plasmodium falciparum , leishmania donovani , natural product , pharmacology , pharmacognosy , protozoa , biology , ehrlich ascites carcinoma , chemistry , stereochemistry , traditional medicine , biological activity , leishmaniasis , biochemistry , medicine , microbiology and biotechnology , malaria , immunology , visceral leishmaniasis , pathology
Synthesis of derivatives of diospyrin, a natural product, has led to the modification of its tumour‐inhibitory effect, in vitro , towards Ehrlich ascites carcinoma and antiparasitic activity against Leishmania donovani in vitro . The present study shows that two of these novel hydroquinoid analogues derived from diospyrin also show enhanced inhibitory effects against Plasmodium falciparum, in vitro , and may be a useful model for the development of novel antimalarial drugs.