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Evaluation of the folklore use of Rhaptopetalum coriaceum olio as an abortifacient
Author(s) -
Onu U. Oden
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090115
Subject(s) - uterus , abortifacient , endocrinology , traditional medicine , medicine , abortion , pregnancy , pharmacology , chemistry , biology , genetics
The antifertility effects of the methanol extract of Rhaptopetalum coriaceum stem bark were investigated in pregnant rats and oestrogen‐primed isolated rat uterus. Graded intraperitoneal doses (350, 700 and 1400 mg/kg) of the extract produced fetal discharges which were expressed as percent antifertility (16.6%, 50.0%, and 66.6% respectively). The extract induced an increase of spontaneous activity of oestrogen‐dominated rat uterus in a concentration‐related manner with an EC 50 of 48.6 mg/mL.