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Cardiovascular effects of the aqueous extract of Moringa pterygosperma
Author(s) -
Limaye Dnyanesh Arun,
Nimbkar Anil Yashvant,
Jain Rajeev,
Ahmad Mansoor
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090109
Subject(s) - inotrope , ileum , blood pressure , dose dependence , stomach , pharmacology , heart rate , moringa , medicine , aqueous extract , traditional medicine , anesthesia , chemistry , endocrinology
The aqueous extract of stem bark of Moriga pterygosperma (Family Moraingaceae) was investigated for its effect on various pharmacological parameters. In cardiovascular profile at lower concentrations (1–10 ng) it produced a dose dependent positive inotropic effect ( n = 3, 1.29 ± 0.021 for 10 ng) and at higher concentrations (0.1–1 μg) a dose dependent negative inotropic effect ( n = 3, 0.53 ± 0.033 for 1 μg) on the isolated frog heart. It also produced a dose dependent hypotensive effect on dog blood pressure ( n = 3, 82 ± 0.98 for 20 mg/kg). It failed to elicit any effect on isolated guinea‐pig ileum, rat stomach fundus or frog rectus abdominis muscle.