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The effects of Icacina trichantha tuber extract on the nervous system
Author(s) -
Asuzu I. U.,
Abubakar I. I.
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090106
Subject(s) - muscle relaxant , pharmacology , medicine , guinea pig , traditional medicine , chemistry , anesthesia
The tuber of Icacina trichantha was extracted with 50% methanol and concentrated to dryness in vacuo to give a yield of 5.6% w/w. The extract induced sleep in rats treated with high doses (400–1000 mg/kg i.p.). The LD 50 of the extract was 671 mg/kg i.p. It potentiated pentobarbitone sleeping time in rats dose‐dependently and also induced significant local anaesthetic effects in guinea‐pigs. The extract was able to give 80% protection to rats poisoned with pentylenetetrazole but failed to protect rats from strychinine poisoning. It induced significant dose‐dependent analgesia in rats and showed significant muscle relaxant activity in mice.