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Antiinflammatory and hepatoprotective effects of Ventilago leiocarpa
Author(s) -
Lin ChunChing,
Lin WeiChih,
Chang ChengHsiung,
Namba Tsuneo
Publication year - 1995
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650090104
Subject(s) - chemistry , infiltration (hvac) , liver injury , pharmacology , anti inflammatory , traditional medicine , antioxidant , necrosis , medicine , biochemistry , physics , thermodynamics
Two animal experiments models including carrageenin‐induced oedema and CCl 4 ‐induced liver injury were investigated to compare and elucidate antiinflammatory and hepatoprotective effects of four fractions (CHCl 3 , EtOAc, n ‐BuOH, H 2 O) from the stem bark of Ventilago leiocarpa Benth. The results showed that each fraction displayed both antiinflammatory and hepatoprotective activities. The H 2 O fraction (50, 100 mg/kg) was even more effective than indomethacin (10 mg/kg) in reducing carrageenin‐induced oedema, and also had the greatest protection against CCl 4 ‐induced liver injury. It significantly lowered the acute increase in sGOT and sGPT levels caused by CCl 4 . Histopathological changes such as necrosis, fatty change, ballooning degeneration and inflammatory infiltration of lymphocytes and Kupffer cells around the central veins were also concurrently improved by the treatment with each fraction (50 mg/kg) or the H 2 O fraction (100 mg/kg).