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Antithrombotic activity of ternatin, a tetramethoxy flavone from Egletes viscosa less
Author(s) -
Souza M. F.,
Cunha G. M. A.,
Fontenele J. B.,
Viana G. S. B.,
Rao V. S. N.,
Silveira E. R.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080808
Subject(s) - antithrombotic , pharmacology , in vivo , bleeding time , platelet , carrageenan , thrombosis , medicine , platelet aggregation , fibrinolytic agent , traditional medicine , biology , immunology , microbiology and biotechnology
Ternatin, a tetramethoxy flavone isolated from Egletes viscosa Less. was evaluated for a possible antithrombotic acitivity on in vitro platelet aggregation induced by ADP and in vivo mouse model of tail thrombosis induced by kappa‐carrageenan (KC). ADP‐induced platelet aggegation was inhibited by ternatin in a concentration‐dependent manner with an IC 50 of 390 μM. It also provided marked protection of mice from thrombotic challenge with KC. Tail thrombosis was totally prevented in mice that received ternatin prophylactically (1 h prior to KC injection) whereas therapeutically (4 h after KC injection) administered ternatin effectively reduced the length of the thrombosed/infarcted part of the tail. The observations suggest an antithrombotic action of ternatin.