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Laminaria ochroleuca : A preliminary study of its effect on the central nervous system
Author(s) -
VázquezFreire M. J.,
Lamela M.,
Calleja J. M.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080709
Subject(s) - depressant , laminaria , motor activity , central nervous system , analgesic , pharmacology , pentobarbital , chemistry , traditional medicine , medicine , biology , botany , algae
The effects were studied of a methanolic extract of the brown alga Laminaria ochroleuca on the central nervous system (CNS) of mice. Spontaneous motor activity, exploratory behaviour, motor coordination, d‐amphetamine‐induced hypermotility, body temperature, pentobarbital‐induced hypnosis, pentylenetetrazole‐induced convulsions and analgesic activity were assessed. At doses between 25 and 100mg/kg, the extract showed significant activity in all tests except that of pentylenetetrazole‐induced convulsions. It is concluded that the methanolic extract of Laminaria ochroleuca is a CNS depressant with slight analgesic activity.