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Hypoglycaemic properties of the aqueous root extract of Morinda lucida (Benth) (Rubiaceae). Studies in the mouse
Author(s) -
Kamanyi A.,
Njamen D.,
Nkeh B.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080612
Subject(s) - rubiaceae , alloxan , traditional medicine , morinda , aqueous extract , body weight , blood sugar , oral administration , pharmacology , chemistry , medicine , diabetes mellitus , botany , biology , endocrinology
The aqueous root extract of Morinda lucida (Rubiaceae) Benth, exhibited potent hypoglycaemic effects in both normoglycemic and alloxan‐induced diabetic mice by oral administration. This effect was dose‐dependent and more potent than that observed with chlorpropamide (1‐(p‐chlorobenzene‐sulphanyl)‐3‐propylurea). In the normoglycaemic mice, the extract (140 mg/kg body weight) produced a fall in blood sugar of 32% + 1% while at 280 mg/kg body weight there was a 52% + 2% fall over the same time interval. In alloxan‐induced diabetic mice, the reaction time of the extract was longer with a single dose of the extract producing a significant hypoglycaemic effect 4 h after administration. In diabetic mice, a dose of 140 mg/kg body weight of the plant extract caused a fall in blood sugar of 51% + 1% while a dose of 280 mg/kg produced a fall of 60% + 2%.