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Inhibitory activity of extracts of Alternanthera brasiliana (amaranthaceae) against the herpes simplex virus
Author(s) -
Lagrota M. H. C.,
Wigg M. D.,
Santos M. M. G.,
Miranda M. M. F. S.,
Camara F. P.,
Couceiro J. N. S. S.,
Costa S. S.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080609
Subject(s) - sephadex , biology , biological activity , pharmacognosy , herpes simplex virus , amaranthaceae , virus , in vitro , toxicity , biochemistry , traditional medicine , microbiology and biotechnology , chromatography , botany , chemistry , enzyme , virology , medicine , organic chemistry
Five extracts from A. brasiliana , obtained through different procedures, showed anti‐HSV activity. The best activity was detected in a fraction (B) that was obtained from the crude cold aqueous extract on Sephadex G 15 . Fraction B showed low cellular toxicity and inhibition from 32.4% to 99.9% at concentrations from 6.2 to 50.0 μg/mL, exhibiting a therapeutic index of 32. Fractions obtained on Sephadex G 100 and reversed‐phase column also showed considerable inhibition. Fraction B did not show any virucidal activity, however, its inhibitory activity was revealed during the later stages of the virus replication cycle. This fraction showed activity on DNA synthesis of infected cells.