Premium
Effects of polysaccharides purified from Salviae miltiorrhizae radix on experimental nephrosis in rats
Author(s) -
Guoji Ye,
Kajihara JunIchi,
Kirihara Sei,
Kato Kazuo,
Abe Hiroko
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080605
Subject(s) - nephrosis , radix (gastropod) , chemistry , polysaccharide , endocrinology , oral administration , medicine , excretion , cholesterol , pharmacology , biochemistry , biology , botany
Abstract A polysaccharide active fraction (AF) obtained from a hot‐water extract of Salviae miltiorrhizae radix was found to reduce urinary protein excretion in rats with aminonucleoside‐induced experimental nephrosis. Its composition was determined as 20% neutral sugars and 80% uronic acids. Oral or intramuscular administration of AF to the rats with aminonucleoside‐induced nephrosis resulted in a significant decrease of urinary protein excretion and an improvement in the levels of serum albumin, cholesterol and lipid peroxide. Further, electron microscopical analysis revealed that the extent and the severity of lesions of the epithelial cells in glomerulus were significantly less in the rats treated with AF.