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Carthami flos extract and its component, stigmasterol, inhibit tumour promotion in mouse skin two‐stage carcinogenesis
Author(s) -
Kasahara Yoshimasa,
Kumaki Kunio,
Katagiri Susumu,
Yasukawa Ken,
Yamanouchi Sakae,
Takido Michio,
Akihisa Toshihiro,
Tamura Toshitake
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080603
Subject(s) - stigmasterol , flos , carthamus , sterol , traditional medicine , tumor promotion , phytotherapy , silybum marianum , flavonoid , carcinogenesis , pharmacognosy , biology , botany , chemistry , biochemistry , biological activity , cholesterol , medicine , antioxidant , chromatography , in vitro , pathology , rutin , gene , alternative medicine
An antitumour‐promoting activity in two‐stage carcinogenesis, is found in the methanol extract of the Carthami Flos ( Carthamus tinctorius L.; Compositae), which is a traditional Chinese medicine and natural pigment of rouge additivies in certain Asian countries. From these active fractions, δ 5 ‐ and δ 7 ‐sterol fractions were separated. The separation was examined for inhibitory activity against TPA‐induced inflammatory ear oedema in mice. Stigmasterol (71% in the mixture) was the most abundant of 14 sterols identified in the δ 5 ‐sterol fraction. Schottenol (70% in the mixture) constituted the dominant sterol of the δ 7 ‐sterol fraction. Furthermore, stigmasterol markedly inhibited tumour promotion in two‐stage carcinogenesis experiments.