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Pharmacological effects of butylidenephthalide
Author(s) -
Ko WunChang,
Chang LiDuang,
Wang GwoYang,
Lin LungChing
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080602
Subject(s) - dilator , medicine , in vivo , vasodilation , pharmacology , contraction (grammar) , antispasmodic , pituitrin , coronary perfusion pressure , blood pressure , perfusion , coronary vasodilator , anesthesia , biology , microbiology and biotechnology , cardiopulmonary resuscitation , resuscitation
The pharmacological effects of synthetic butylidenephthalide (Bdph), the most potent antispasmodic agent found in the neutral oil of Ligusticum wallichii Franch., were examined in this study. In vivo , Bdph exerted a significant antihypertensive effect in anaesthetized renal hypertensive rats at a dose of 30 mg/kg (i.v. or i.p.), or 60 mg/kg (p.o.). Bdph antagonized noradrenaline (NA) induced increases in blood pressure in anaesthetized normotensive rats. In addition, Bdph prevented the pituitrin‐induced T‐wave lowering of the ECG in anaesthetized rats. It also dose‐dependently decreased coronary arterial pressure in dogs. It is concluded that Bdph dilates coronary vessels. In vitro , Bdph non‐competitively antagonized adrenaline‐induced contraction in isolated rabbit aortic strips. It also significantly antagonized the NA‐induced maximum decrease in perfusion rate of isolated rabbit ears. However, the vasodilator effect may cause a heat loss because Bdph significantly lowered the rectal temperature of rats at ambient temperature of 20°C, but not at 30°C. Bdph might be a useful coronary dilator and antihypertensive drug.