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Cholertic activity of Thapsia chem I, II, and III in rats: Comparison with terpenoid constituents and peppermint oil
Author(s) -
Trabace Luigia,
Avato Pinarosa,
Mazzoccoli Michele,
SiroBrigiani Giovanni
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080511
Subject(s) - menthol , terpenoid , chemotype , choleretic , chemistry , pharmacognosy , traditional medicine , essential oil , chromatography , biological activity , stereochemistry , biology , organic chemistry , biochemistry , medicine , in vitro , pharmacology
The influence on bile flow of the fruit essence from three chemotypes of the genus Thapsia and their major components has been investigated. For comparative purposes menthol and peppermint oil were also included in the assay. All the drugs tested showed toa different extent choleretic activity calculated on the increase of the bile amount in male adbult Wistar rats. Thapsia Chem I (50 mg/kg) containing 88% geranylacetate was found to indued choleresis in treated rats to a level as high as peppermint oil containing 42% menthol. A similar activity was confirmed when pure geranylacetate was assayed.