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Hepatoprotective studies of a fraction from the fruits of Terminalia belerica roxb. On experimental liver injury in rodents
Author(s) -
Anand K. K.,
Singh B.,
Saxena A. K.,
Chandan B. K.,
Gupta V. N.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080507
Subject(s) - lipid peroxidation , carbon tetrachloride , liver injury , bilirubin , pharmacology , toxicity , microsome , paralysis , ccl4 , chemistry , medicine , biochemistry , antioxidant , surgery , enzyme , organic chemistry
The effects of an orally administered fraction (TB5) from the fruits of Terminalia belerica in experimental liver injury induced by carbon tetrachloride (CCI 4 ) were studied. Hexobarbitone‐induced sleep, zoxazolamine‐induced paralysis, transaminases, bilirubin, total protein in serum and microsomal lipid peroxidation and triglycerides in liver were used as indices of liver injury. A significant hepatoprotective effect was observed as evident from shortened hexobarbitone ‘sleep time’ and zoxazolamine ‘paralysis time’ when compared with CCI 4 alone. Pre‐ and post‐treatment of TB5 reduced, in a dose dependent manner, the elevated levels of serum tranaminases and bilirubin in rats, thus demonstrating its effect both as a prophylactic and curative. Its protective effects on microsomal lipid peroxidation and triglycerides in liver suggest a restorative effect in the process of CCI 4 ‐induced liver damage. TB5 did not show any signs of toxicity up to oral doses of 3.2 g/kg in mice.