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The ethanol‐insoluble fraction of an aqueous Cervi Cornu Vernum extract improves the condition of renal anaemia in rats fed an adenine diet
Author(s) -
Yokozawa Takako,
Ogama Takako,
Namba Tsuneo,
Hattori Masao
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080505
Subject(s) - mean corpuscular volume , albumin , medicine , ethanol , endocrinology , red blood cell , red cell , chemistry , biochemistry , hematocrit
Levels of red blood cell count (RBC), haemoglobin (Hb) and haematocrit (Ht) were decreased significantly in rats fed an adenine diet. Their erythrocyte indices, such as mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC), were similar to those of normal rats, but uraemic symptoms were present as well, providing evidence of renal anaemia. Administration of the EtOH‐insoluble fraction of an aqueous extract of Cervi Cornu Vernum improved the renal anaemia, and the changes were reflected in the morphology of the erythrocytes. Furthermore, there was a significant increase in total protein and albumin. These findings suggest that the EtOH‐insoluble fraction of Cervi Cornu Vernum improves the state of undernutrition resulting from renal anaemia.