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Short term toxicity of embelin in female rats
Author(s) -
Prakash Anand O.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080502
Subject(s) - endocrinology , kidney , glycogen , medicine , toxicity , spleen , muscle hypertrophy , alkaline phosphatase , pathological , acid phosphatase , body weight , adrenal gland , oral administration , biology , physiology , enzyme , biochemistry
The toxicity of emblin has been assessed in female cyclic rats. Its administration at a dose of 120 mg/kg body weight did not cause any changes in the weight of liver, kidney and spleen, however, the wet weight of the adrenals showed a remarkable increase. Biochemical constituents such as protein and glycogen did not show any change in these organs except in the adrenal where a significant increase was observed. The activity of acid and alkaline phosphatase was increased in the kidney and adrenal. Administration of embelin for 6 weeks caused severe pathological changes in the liver and kidney which mainly included disintegration, necrotic changes and perinuclear vacuolation. Marked tubular damage was observed in the kidneys. The adrenals showed hypertrophy and the histological features of the spleen remained unchanged.