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Pharmacological activity of the extracts of two Satureja obovata varieties on isolated smooth muscle preparations
Author(s) -
de Rojas V. R. Sánchez,
Ortega T.,
Villar A.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080405
Subject(s) - acetylcholine , smooth muscle , pharmacognosy , satureja , vasodilation , antispasmodic , aorta , inhibitory postsynaptic potential , pharmacology , chemistry , biological activity , traditional medicine , biology , medicine , biochemistry , endocrinology , chromatography , in vitro , essential oil
Aqueous extracts of two varieties of Satureja obovata Lag. subsp. obovata : var. valentina and var. obovata , exhibited a dose‐dependent inhibitory effect on the contractions induced by acetylcholine (Ach) (3.4 × 10 −8 −6.8 × 10 −5 M) and CaCl 2 (2 × 10 −4 −1.28 − 10 −2 M) in rat duodenum and by noradrenaline (NA) (10 −9 −5.12 × 10 −7 M) and CaCl 2 (2 × 10 −4 −1.28 × 10 −2 M) in rat aorta. The extracts also produced relaxant effects in both tissue preparations precontracted with K + (75 mM) and in rat aorta precontracted with NA (10 −6 M). Vasodilatory effects of the two extracts were attenuated when the endothelium was removed. The inhibitory effects of var. valentina were stronger. These results indicated a smooth muscle relaxant effect that could account for the use of these extracts in traditional medicine.