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The antiinflammatory and liver protective effects of Boussingaultia gracilis var. pseudobaselloides extract in rats
Author(s) -
Lin ChunChing,
Sung TuanChing,
Yen MingHong
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080403
Subject(s) - biology , carrageenan , brood , necrosis , pharmacology , botany , medicine
The pharmacological effects of Boussingaultia gracilis var. pseudobaselloides was studied against carrageenaninduced paw oedema, CCI 4 and D‐galactosamine (D‐GalN) induced hepatotoxicity in rats. The water extracts of B. gracilis var. pseudobaselloides (leaf, stem, brood bud) were found to maintain significant antiinflammatory activity against carrageenan‐induced oedema. The administration of the brood bud extract (300 mg/kg) was more potent than indomethacin (10 mg/kg). Moreover, the water extracts of B. gracilis var. pseudobaselloides (leaf, stem, brood bud) significantly decreased the acute increase in serum GOT and GPT levels caused by CCI 4 and D‐GalN. Histological changes such as necrosis, fatty change, ballooning degeneration, inflammatory infiltration of lymphocytes and Kupffer cells around the central vein (CCI 4 ‐induced hepatotoxicity) and portal vein (D‐GalN induced hepatotoxicity), were simultaneously improved by the treatment with B. gracilis var. pseudobaselloides (leaf, stem, brood bud).