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Antiulcer effect of flavonoids. Role of endogenous PAF
Author(s) -
Izzo A. A.,
Carlo G. Di,
Mascolo N.,
Capasso F.,
Autore G.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080313
Subject(s) - naringin , flavonols , kaempferol , rutin , platelet activating factor , endogeny , quercetin , pharmacology , chemistry , dose dependence , flavonoid , pharmacognosy , ethanol , biological activity , traditional medicine , biochemistry , antioxidant , medicine , in vitro , chromatography
Abstract Quercetin, rutin and kaempferol, administered intraperitoneally (25–100 mg/kg) inhibited dose‐dependently gastric damage produced by acidified ethanol in rats. Flavone was inactive while naringin was active at higher dose (200 mg/kg). The flavonols tested inhibited dose‐dependently the mucosal content of platelet‐activating factor (PAF) suggesting that the protective effects of these substances may be mediated by endogenous PAF.