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Selective antiprotozoal activity of some Strychnos alkaloids
Author(s) -
Wright Colin W.,
Allen David,
Cai Ya,
Chen Zhenping,
Phillipson J. David,
Kirby Geoffrey C.,
Warhurst David C.,
Tits Monique,
Angenot Luc
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080306
Subject(s) - antiprotozoal , entamoeba histolytica , plasmodium falciparum , protozoa , in vitro , cytotoxic t cell , biology , traditional medicine , cytotoxicity , pharmacology , chemistry , microbiology and biotechnology , biochemistry , medicine , immunology , malaria
The in vitro activities of 20 Strychnos alkaloids have been determined against three species of protozoa and the active compounds were then assessed for in vitro cytotoxic activity using KB cells. 3′,4′‐dihydrosambarensine was the most active against Plasmodium falciparum , and was relatively nontoxic to KB cells (cytotoxic/antiprotozoal ratio, 1474). Usambarensine displayed the most selectivity against Entamoeba histolytica while 3′,4′‐dihydrousambarensine was the most selective compound against Giardia intestinalis although the cytotoxic/antiprotozoal ratios (20.4 and 6.6 respectively) were less favourable than the above.