Hypolipidaemic and antiatherosclerotic effects of oral  Gymnema sylvestre  R. Br. Leaf extract in albino rats fed on a high fat diet | Zendy

Bishayee Anupam | Zendy; Chatterjee Malay | Zendy

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Hypolipidaemic and antiatherosclerotic effects of oral Gymnema sylvestre R. Br. Leaf extract in albino rats fed on a high fat diet

Author(s) -

Bishayee Anupam,

Chatterjee Malay

Publication year - 1994

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650080216

Subject(s) - gymnema sylvestre , triglyceride , pharmacognosy , very low density lipoprotein , cholesterol , high density lipoprotein , hyperlipidemia , chemistry , medicine , endocrinology , lipoprotein , phytotherapy , clofibrate , traditional medicine , biology , biological activity , biochemistry , diabetes mellitus , in vitro , alternative medicine , pathology

Gymnema sylvestre R. Br. leaf extract (25–100 mg/kg) when orally administered to experimentally induced hyperlipidaemic rats for 2 weeks, reduced the elevated serum triglyceride (TG), total cholesterol (TC), very low‐density lipoprotein (VLDL)‐and low‐density lipoprotein (LDL)‐cholesterol in a dose‐dependent manner. The decreased serum high‐density lipoprotein (HDL)‐cholesterol and antiatherogenic index (AAI) in hyperlipidaemia were also reversed towards normalization. The ability of this extract (at 100 mg/kg) to lower TG and TC in serum and its antiatherosclerotic potential were almost similar to that of a standard lipid lowering agent—clofibrate.

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