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Oligo‐ and macrocyclic diterpenes in thymelaeaceae and Euphorbiaceae occurring and utilized in Yunnan (Southwest China). 6. Tigliane type diterpene esters from latex of Euphorbia prolifera
Author(s) -
Dagang Wu,
Sorg B.,
Hecker E.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080209
Subject(s) - diterpene , euphorbiaceae , thymelaeaceae , euphorbia , stereochemistry , pharmacognosy , chemistry , biology , botany , traditional medicine , biological activity , biochemistry , medicine , in vitro
Abstract Five tigliane type diterpene esters were isolated from the latex of Euphorbia prolifera Buch‐Hom by means of Craig distribution followed by thin layer chromatography. Structural elucidations were done by spectroscopic methods (MS, NMR) and revealed the following Euphorbia factors: Pr 1 to be a 12,13‐diester of 4,20‐dideoxyphorbol (12‐benzoate‐13‐isobutyrate), Pr 2 , Pr 3 : to be 12,13‐diesters of 4,20‐dideoxy‐5ξ‐hydroxyphorbol (12‐benzoate‐13‐isobutyrate and 12,13‐diisobutyrate, respectively), Pr 4 /Pr 5 : to be a mixture of 12,13‐diesters of 4‐deoxyphorbol [12‐(2,4‐decadienoate)‐13‐isobutyrate/12‐(2,4,6‐decatrienoate)‐13‐isobutyrate]. All compounds were assayed on the mouse ear for irritant activity: Pr 1 was weakly and the mixture Pr 4 /Pr 5 was highly active, Pr 2 and Pr 3 were practically inactive.