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The antioxidant activity of Flavonoids Isolated from Corylus colurna
Author(s) -
Benov L.,
Georgiev N.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080208
Subject(s) - myricetin , rutin , quercetin , antioxidant , chemistry , free radical scavenger , radical , superoxide , scavenger , flavonoid , biochemistry , traditional medicine , medicine , enzyme , kaempferol
A natural mixture of flavonoids (F 4 ) was isolated from Corylus colurna leaves. In this study the antioxidant and the free radical scavenging activities of this mixture have been investigated. It was found that F 4 had a strong antioxidant activity comparable to that of quercetin and myricetin and higher than that of rutin. F 4 is a potent superoxide radical scavenger, more efficient than quercetin and myricetin or their mixture. F 4 is also a strong inhibitor of ischaemia/reperfusion‐induced peroxidation in the brain and liver. In addition to these advantages F 4 had low toxicity and can be readily isolated. All these advantages make it an alternative to the more toxic synthetic antioxidants for the treatment of pathological conditions in which free radicals are involved.