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Effects of stembark and leaf extracts of Bridelia ferruginea on skeletal muscle
Author(s) -
Onoruvwe O.,
Olayinka A. O.,
Lot T. Y.,
Udoh F. V.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080109
Subject(s) - extracellular , intracellular , bark (sound) , stimulation , skeletal muscle , chemistry , contracture , pharmacology , medicine , traditional medicine , biology , biochemistry , anatomy , surgery , ecology
Abstract The ethanolic extracts of the leaves and stembark of Bridelia ferruginea were separately investigated for their effects on skeletal muscle using the phrenic nerve‐hemidiaphragm muscle preparation from rats. The bark extract inhibited twitch tension induced by direct electrical stimulation (muscle) (MS) but not indirect electrical stimulation (nerve) (NS) of the diaphragm. It inhibited tetanus tension to both nerve (TNS) and muscle stimulation (TMS), had no effect on K + ‐induced contracture and reduced the minimal fusion frequency (MFF). The leaf extract had no effect on twitch tension to NS and MS or K + ‐induced contracture but increased tetanus tension to TNS or TMS as well as MFF. These findings suggest that the bark extract does not affect influx of extracellular Ca 2+ but inhibits the intracellular mobilization of Ca 2+ . The leaf extract also had no effect on influx of extracellular Ca 2+ but most likely facilitated the intracellular mobilization of Ca 2+ . Thus, the intracellular action of the bark extract is opposite to that of the leaf extract.