Premium
Oestrogenic rhythm induced by a single administration of the extract of Ferula jaeschkeana to immature rats
Author(s) -
Prakash A. O.,
Pathak Sandhya,
Shaiv Amita,
Mathur R.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080107
Subject(s) - uterus , glycogen , oral administration , endometrium , medicine , endocrinology , rhythm , biology
The hexane extract of Ferula jaeschkeana was studied for its effects on the oestrogenic rhythm following a single administration to immature rats. A 25 mg/kg single oral dose significantly increased the uterine wet weight and caused premature opening of the vagina and induced vaginal cornification. A uterotrophic peak was attained 2 days after administration and thereafter declined gradually. At 10 days, values became almost normal. A significant amount of glycogen was estimated in the uterus during the first 5 days after administration and thereafter decreased significantly. Histoarchitecture of the uterus showed a stimulated endometrium which continued for 6–8 days only. The oestrogenic rhythm induced by the hexane extract was compared with that following diethylstilbesterol administration.