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In vitro antimalarial activity, chloroquine potentiating effect and cytotoxicity of alkaloids of Hernandia voyronii Jum. (Hernandiaceae)
Author(s) -
RatsimamangaUrverg S.,
Rasoanaivo P.,
Milijaona R.,
Rakotoarimanga J.,
Rafatro H.,
Robijaona B.,
RakotoRatsimamanga A.,
Verdier F.,
le Bras J.
Publication year - 1994
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650080105
Subject(s) - chloroquine , plasmodium falciparum , cytotoxicity , in vitro , pharmacology , hela , adjuvant , biological activity , bioassay , mechanism of action , pharmacognosy , traditional medicine , chemistry , biology , malaria , biochemistry , medicine , immunology , genetics
Hernandia voyronii is traditionally used as adjuvant to chloroquine in Madagascar. Neutral and basic alkaloidal extracts of this plant were evaluated for their intrinsic in vitro antimalarial activity, cytotoxicity and chloroquine potentiating action against the chloroquine resistant Plasmodium falciparum strain FCM29. Bioassay directed fractionation clearly demonstrated that both the intrinsic antimalarial activity and the chloroquine potentiating action was localized in the polar alkaloidal extract. Moreover, this extract had low cytotoxicity to HeLa cells and L929 fibroblasts. These results support the traditional use of H. voyronii as an antimalarial and adjuvant to chloroquine.