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Neuroendocrinological approach for examining the mechanisms of action of Toki‐Shakuyaku‐San (TJ‐23) on the activity of tyrosine hydroxylase in the brain
Author(s) -
Toriizuka Kazuo,
Hagino Nobuyoshi,
Terasawa Katsutoshi
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070721
Subject(s) - tyrosine hydroxylase , medicine , endocrinology , kampo , ventral tegmental area , ovariectomized rat , hypothalamus , hippocampus , midbrain , immunohistochemistry , central nervous system , dopamine , estrogen , pathology , alternative medicine , dopaminergic
Administration of the Kampo medicine, TJ‐23, to ovariectomized rats resulted in decreased tyrosis hydroxylase (TH) activity in the dorsal hippocampus but an increased activity in the ventral tegmental area. A decrease of TH activity in the hypothalamus was not statistically significant. The effect of TJ‐23 was compared to oestrogen in a similar group of rats and it was concluded that the standard drug and TJ‐23 induced similar effects.