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Neuroprotective effect of Toki‐Shakuyaku‐San (TJ‐23) on hypoglycaemia/hypoxia‐induced neuronal damage in rat striatal slices
Author(s) -
Kataoka Yasufumi,
Kouzuma Masami,
Koizumi Shuichi,
Niwa Masami,
Taniyama Kohtaro,
Fujiwara Michihiro
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070720
Subject(s) - nifedipine , neuroprotection , antagonist , glutamate receptor , hypoxia (environmental) , endocrinology , medicine , ischemia , nmda receptor , chemistry , pharmacology , biology , receptor , calcium , oxygen , organic chemistry
The effect of Toki‐Shakuyaku‐San (TJ‐23) was examined on various models of brain damage in vitro. TJ‐23 (10 mg/mL) significantly protected striatal slices from dysfunction induced by high K + and BAY K‐8644 but not from that by L ‐glutamate and N ‐methyl‐ D ‐aspartate, an effect which was similar to that of nifedipine, a Ca 2+ antagonist. The present findings, therefore, raised the possibility that TJ‐23 expressed a neuroprotective action on hypoxia/ischaemia‐induced brain damage by inhibiting an excess Ca 2+ entry through voltage‐gated Ca 2+ channels.