Premium
Toki‐Shakuyaku‐San and Oren‐Gedoku‐To improve the disruption of spatial cognition induced by cerebral ischaemia and central cholinergic dysfunction in rats
Author(s) -
Fujiwara Michihiro,
Iwasaki Katsunori
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070718
Subject(s) - kampo , medicine , cholinergic , ischemia , neurotransmitter , endocrinology , anesthesia , pharmacology , central nervous system , pathology , alternative medicine
The effects of traditional Kampo prescriptions, Toki‐Shakuyaku‐San and Oren‐Gedoku‐To, were compared on the improvement of experimental disruption of spatial cognition using an eight‐arm radial maze task in rats. These two Kampo prescriptions, Toki‐Shakuyaku‐San at a dose of 100 and 200 mg/kg, p.o. and Oren‐Gedoku‐To at a dose of 5 and 10 mg/kg, p.o., improved the disruption of spatial cognition in a non‐dose‐dependent manner in both scopolamine (0.5 mg/kg, i.p.) and cerebral ischaemia (10 min) treated rats. At high doses of the drugs, these ameliorative effects were diminished. These results suggest that the balance between several neurotransmitter systems may play a significant role in learning and memory performance. Ameliorative effects of Toki‐Shakuyaku‐San resulted in 50% of rats recovering to normal, in the group treated with scopolamine compared with the cerebral ischaemia group. Oren‐Gedoku‐To, on the other hand, improved the efficacy against ischaemia.