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Antigastric ulcer effects in rats of Aloe arborescens Miller var. natalensis Berger extract
Author(s) -
Teradaira R.,
Shinzato M.,
Beppu H.,
Fujita K.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070712
Subject(s) - traditional medicine , pylorus , acetic acid , ulcer index , ligation , phytotherapy , pharmacognosy , chemistry , pharmacology , botany , medicine , biological activity , biochemistry , biology , gastric mucosa , stomach , in vitro , pathology , alternative medicine
The antigastric effects of Aloe arborescens Miller var. natalensis Berger extract with high molecular weight components ((A) MW over 5000 and (B) MW over 50 000)) were examined by changes of ulcer index with three different experimental models in rats. The suppressive effects were evaluated under (1) stress (immobilization in water) and (2) ligation of pylorus, and the healing effects were likewise examined with the (3) acetic acid test. Both fractions showed a slight suppressive effect on the stressed animals. However, in the groups with pylorus ligation, Aloe extract (A) significantly disclosed suppressive effects. Furthermore, the same Aloe fraction heated at 100°C for 15 min also demonstrated a significant effect on animals with pylorus ligation. Rats induced with acetic acid exhibited a significant healing effect. However, fraction (B) produced only a slight beneficial effect. These results suggest the existence of both suppressive and healing substances on gastric ulcer in the Aloe extract within the range of MW 5000–50 000. These effects were confirmed by micro‐ and macroscopic findings.