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Mechanism of antiinflammatory and antithermal burn action of CPase from Aloe arborescens Miller var. natalensis Berger in rats and mice
Author(s) -
Obata Masafumi,
Ito Shosuke,
Beppu Hidehiko,
Fujita Keisuke,
Nagatsu Toshiharu
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070711
Subject(s) - pharmacognosy , pharmacology , mechanism of action , traditional medicine , vascular permeability , medicine , biology , biological activity , endocrinology , biochemistry , in vitro
Abstract Carboxypeptidase (CPase) was partially purified from Kidachi aloe ( Aloe arborescens Miller var. natalensis Berger) by an FPLC system, and was administered intravenously to female ICR mice with inflammation. The enzyme preparation exhibited significant analgesic effects and inhibited vascular permeability in the abdominal region. It also revealed an antithermal burn action on the hind paw, when it was administered to female Wistar rats intravenously.