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Antidiarrhoeal activity of the methanolic fraction of the extract of unripe fruits of Psidium guajava Linn.
Author(s) -
Ghosh T. K.,
Sen T.,
Das Arunima,
Dutta A. S.,
Nag Chaudhuri A. K.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070610
Subject(s) - psidium , antidiarrhoeal , traditional medicine , fraction (chemistry) , vibrio cholerae , phytochemical , biology , pharmacognosy , chemistry , botany , microbiology and biotechnology , bacteria , biological activity , in vitro , medicine , biochemistry , chromatography , castor oil , genetics
The methanolic fraction of the extract of unripe fruits of Psidium guajava was found to possess significant antidiarrhoeal activity. The fraction decreased gastric motility in an experimental animal model and inhibited acetylcholine release from isolated guinea‐pig ileum. On microbial screening the fraction was found to inhibit significantly the growth of different strains of Shigella spp. and Vibrio cholerae .