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Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
Author(s) -
De Farias Freire Sonia Maria,
Da Silva Emim José Artur,
Lapa Antonio José,
Souccar Caden,
Torres Luce Maria Brandão
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070605
Subject(s) - analgesic , pharmacology , pentobarbital , phytotherapy , antipyretic , chemistry , medicine , alternative medicine , pathology
Abstract The analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 g/kg) p.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5–2 mg/kg i.v.) to anaesthetized rats induced a dose‐related hypertension inhibited by alpha‐blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25‐1 g/kg p.o.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg p.o.), a major triterpene obtained from EE, produced the same effect. The tail flick response of mice was not influenced by either extract. EE (0.5 and 1 g/kg) and glutinol (30 mg/kg) p.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast‐induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process.