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Inhibitory effects of monomeric and dimeric phenylpropanoids from mace on lipid peroxidation In Vivo and In Vitro
Author(s) -
Hattori Masao,
Yang XiuWei,
Miyashiro Hirotsugu,
Namba Tsuneo
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070603
Subject(s) - lipid peroxidation , ascorbic acid , chemistry , biochemistry , in vivo , antioxidant , pharmacology , biology , food science , microbiology and biotechnology
Repeated p.o. administration of myristicin and dehydrodiisoeugenol, monomeric and dimeric phenylpropanoids from mace, resulted in suppression of the lipid peroxidation in the liver of mice, which was induced by repeated i.p. injection of FeCl 2 –ascorbic acid–ADP. In addition, a slight decrease of SOD activity by treatment with FeCl 2 –ascorbic acid–ADP was recovered by administration of these compounds. Various constituents isolated from mace inhibited the lipid peroxidation in a rat liver homogenate, which was induced by FeCl 2 –ascorbic acid, CCl 4 –NADPH or ADP–NADPH. Of these compounds, 2,3‐dihydro‐7‐methoxy‐3‐methyl‐2‐ (3,4‐methylenedioxyphenyl)‐5‐propenylbenzofuran, myristicanol‐B and 7‐hydroxymyristicin strongly inhibited the FeCl 2 –ascorbic acid‐induced lipid peroxidation by 70%–100% at 0.1–0.2 mM, and most of the constituents also strongly inhibited the ADP–NADPH‐induced lipid peroxidation at the same concentrations. On the other hand, these compounds weakly inhibited the CCl 4 –NADPH‐induced lipid peroxidation. On the basis of the above findings, myristicin and dehydrodiisoeugenol administered to mice may inhibit the lipid peroxidation in the liver possibly by scavenging free radicals or active oxygen species directly.