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Diuretic activity of Satureja montana subsp. Montana extracts and oil in rats
Author(s) -
Stanic Gordana,
Samaržija Ita
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070508
Subject(s) - satureja , diuretic , diuresis , essential oil , chemistry , pharmacology , urine output , oral administration , traditional medicine , urine , body weight , medicine , kidney , endocrinology , chromatography , biochemistry , renal function
Three preparations of Satureja montana subsp. montana leaves were tested for diuretic activity in rats: an infusion, a water‐alcohol extract and essential oil. In 1‐day experiments, the cumulative volume of urine was collected during the first 5 h after oral administration of 5 mL/100 g body weight of plant preparation. It was established that all the preparations tested initially caused a decrease in diuresis and subsequently a mild stimulation of diuresis. 0.1% solution of essential oil was considered to be a therapeutic dose, whereas 0.5% and 1% solutions caused toxic symptoms in the animals. A further experiment involving treatment of rats for 3 days with a 10% drug infusion and 0.1% essential oil solution demonstrated the considerable diuretic activity of winter savory.