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Antioedema and analgesic actions of Diodia scandens extract in rats and mice
Author(s) -
Akah P. A.,
Okogun J. I.,
Ekpendu T. O.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070412
Subject(s) - analgesic , traditional medicine , pharmacognosy , pharmacology , medicine , phytotherapy , biology , biological activity , alternative medicine , in vitro , biochemistry , pathology
An extract of Diodia scandens obtained by petroleum ether extraction of the leaves was screened for pharmacological actions. The extract evinced a marked antiinflammatory effect in rats, causing a dose‐related and sustained inhibition of the increase in rat paw circumference caused by subplantar injection of a phlogistic agent. In addition, the extract increased the threshold of pain stimulus in mice. The extract significantly protected rats from aspirin, indomethacin and reserpine induced ulcers. These results revealed that the plant, Diodia scandens has potential medicinal value.