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Interaction of capsaicin with human erythrocyte membranes
Author(s) -
De Amit Krishna,
Sengupta D.,
Ghosh J. J.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070410
Subject(s) - haemolysis , capsaicin , ruthenium red , erythrocyte membrane , acetylcholinesterase , red blood cell , membrane , chemistry , cholinesterase , aché , pharmacology , biochemistry , endocrinology , enzyme , medicine , immunology , calcium , receptor
Capsaicin (8‐methyl‐ n ‐vanillyl‐6‐nonenamide) caused a dose related (1‐100 nM) haemolysis of human red blood cells. This haemolysis was associated with significant changes in erythrocyte membrane lipid components and acetylcholinesterase (AChE) activity. Ruthenium red blocks this capsaicin‐induced haemolysis and membrane AChE activity changes.