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Cytotoxic constituents of the roots of the indonesian medicinal plant Fibraurea chloroleuca
Author(s) -
Dai JinRui,
Chai Heebyung,
Pezzuto John M.,
Kinghorn A. Douglas,
Tsauri Soefjan,
Padmawinata Kosasih
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070406
Subject(s) - traditional medicine , chloride , alkaloid , menispermaceae , pharmacognosy , cytotoxic t cell , berberine , biology , cancer cell lines , botany , cell culture , chemistry , biological activity , cancer cell , in vitro , pharmacology , biochemistry , medicine , cancer , organic chemistry , genetics
Abstract Three protoberberine alkaloids, berberine chloride, berberrubine chloride and thalifendine chloride were isolated from the roots of Fibraurea chloroleuca Miers, and found to show significant cytotoxic activity with one or more human cancer cell‐lines and cultured P‐388 cells. A phytoecdysteroid, 20‐hydroxyecdysone, was also isolated as a noncytotoxic compound. Based on comparison with previous investigations, different collections of F. chloroleuca roots appear to exhibit considerable variation in their alkaloidal profiles.