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Effect of some bisbenzylisoquinoline alkaloids on American Leishmania sp. in BALB/c mice
Author(s) -
Fournet Alain,
Barrios Alcira Angelo,
Muñoz Victoria,
Hocquemiller Reynald,
Cavé André
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070404
Subject(s) - alkaloid , pharmacology , berberidaceae , balb/c , menispermaceae , leishmania , pharmacognosy , traditional medicine , chemistry , medicine , biology , immunology , parasite hosting , biological activity , biochemistry , in vitro , stereochemistry , immune system , world wide web , computer science
Four bisbenzylisoquinoline alkaloids, antioquine, berbamine, gyrocarpine and isotetrandrine were tested in BALB/c mice infected with Leishmania amazonensis (IFLA/BR/67/PH8 or MHOM/GF/84/CAY‐H‐142) or L. venezuelensis (VE/74/PM‐H3). The treatments were initiated 1 day after the parasitic infection, with alkaloid at 100 mg/kg/day for 14 days and the reference compound, meglumine antimonate (Glucantime R ) at 200 mg/kg/day. Antioquine, berbamine and gyrocarpine were less potent than Glucantime against L. amazonensis (PH8). Only isotetrandrine exhibited activity approximately equal to or greater than Glucantime in BALB/c mice infected with L. amazonensis (PH8 or H‐142) and showed significant activity against L. venezuelensis . Experiments with a single local treatment on the footpad, 2 weeks after parasitic infection with L. amazonensis (PH8), showed that isotetrandrine at 200 mg/kg was less active than Glucantime at 400 mg/kg.