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Mutagenic potencies of medicinal plants screened in the ames test
Author(s) -
Bresolin Sayonara,
Ferrão Vargas Vera Maria
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070312
Subject(s) - ames test , traditional medicine , strain (injury) , pharmacognosy , biology , folk medicine , chemistry , stereochemistry , biological activity , in vitro , biochemistry , medicine , salmonella , bacteria , genetics , anatomy
Aqueous extracts of three species used in Brazilian popular medicine ( Sambacus australis, Bauhnea forficata, Mimosa bimucromata ) were screened for the presence of mutagenic activity in the Ames test. The extracts showed frameshift mutagenic activity after metabolization. In addition, M. bimucromata presented positive results in the TA100 strain, which detects a base pair substitution, with and without metabolization. The metabolites of B. forficata extract also showed mutagenic activity in the TA102 strain. The presence of flavonoids and tannins in the extracts may be correlated to positive mutagenic activity.