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Formulation studies on Datura metel Linn. Powder 1. Effect of powder size on granule and compact properties
Author(s) -
FemiOyewo M. N.,
Elujoba A. A.,
Alebiowu G.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070311
Subject(s) - angle of repose , granule (geology) , granulation , particle size , materials science , wetting , composite material , chemistry
Abstract Datura metel Linn. powdered leaf (25% w/w) has been formulated in lactose‐based granulations into compacts using the wet granulation process. The effects of changes in the particle size of D. metel powder on the properties of its granules and compacts were studied. Bigger and less friable granules were produced with increase in powder size due to the increased wettability of the powder with size. These resulted in stronger and less friable compacts with a longer disintegration time. Granule flow rate increased while angle of repose decreased with increase in D. metel powder size. Compacts of comparable physical properties were produced from both granulations of D. metel and D. stramonium . The hyoscine contents of D. metel and D. stramonium powders were found to be 0.23% and 0.30% w/w, respectively.