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Influence of Padma 28 on patients with chronic active hepatitis B
Author(s) -
Gładysz Andrzej,
Juszczyk Jacek,
Brzosko Witold J.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070307
Subject(s) - hbeag , medicine , hbsag , serology , gastroenterology , hepatitis b virus , hepatitis b , immunology , hepatitis , antibody , virus
Thirty‐four patients with chronic active hepatitis B (CAH‐B) were treated with Padma 28, a herbal remedy with immunocorrective properties. The patients were monitored by clinical and biochemical testing, as well as by serological, immunological and histological techniques. After treatment lasting 1 year 26 of 34 patients (76.5%) improved or normalized in biochemical parameters as well as in total T‐cell count (CD3) and CD4/CD8 index. An improvement in histology was seen in 19 patients (55.9%). An influence of Padma 28 on the serological markers of HBV infection was seen in 26 of 34 patients (76.5%). Six patients of 34 eliminated HBsAg (17.6%) and four of them seroconverted to anti‐HBs. Eleven patients eliminated HBeAg and HBV‐DNA, and eight of them seroconverted to anti‐HBe. Eight patients with persistent HBs and HBe‐antigenaemia had a decreased titre of HBsAg and HBeAg. In eight patients (23.5%) no influence of Padma 28 on serological markers of HBV infection was seen throughout the observation period. These observations indicate that treatment with Padma 28 of patients with CAH‐B fulfils two of the most important tasks for drug therapy of the disease, it influences the activity of genes of HBV and stops the progression of liver inflammation.