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Renal responses to magnesium lithospermate B in rats with adenine‐induced renal failure
Author(s) -
Yokozawa Takako,
Lee Tae Woong,
Oura Hikokichi,
Hattori Masao,
aka GenIchiro,
Nishioka Itsuo
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070305
Subject(s) - creatinine , blood urea nitrogen , medicine , endocrinology , renal function , magnesium , urea , pharmacology , excretion , chemistry , biochemistry , organic chemistry
A study was conducted to investigate the effects of magnesium lithospermate B on the uraemic symptoms and development of hypertension in rats with adenine‐induced renal failure. Chronic administration of 10 mg/kg body weight/day magnesium lithospermate B significantly reduced serum urea nitrogen, creatinine, methylguanidine, guanidinosuccinic acid and inorganic phosphate, accompanied by increased urinary excretion of urea, creatinine and electrolytes. In addition, renal tissue blood flow was significantly increased and mean blood pressure significantly decreased in the magnesium lithospermate B‐treated group compared with the control group. These results confirm that chronic administration of magnesium lithospermate B to rats with adenine‐induced renal failure ameliorates the uraemic symptoms and development of hypertension by improving renal haemodynamics and electrolyte metabolism.