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Effects of Dan Shen preparations on blood and urine components in rats with renal failure
Author(s) -
Yokozawa Takako,
Oura Hikokichi,
aka GenIchiro,
Nishioka Itsuo
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070304
Subject(s) - urine , blood urea nitrogen , urea , magnesium , chemistry , traditional medicine , pharmacology , kidney , chromatography , medicine , endocrinology , biochemistry , organic chemistry
Two Dan Shen preparations commercially available in China were given intraperitoneally to rats with renal failure in order to investigate their effects on blood and urine components. In rats given an injection of compound Dan Shen composed of Dan Shen and Jiang Xiang, effects similar to those found after administration of magnesium lithospermate B (the active constituent of Dan Shen) alone were observed. In contrast, in rats given noncompound Dan Shen containing almost no magnesium lithospermate B as revealed by high‐performance liquid chromatographic analysis, there was a significant decrease only in the blood levels of urea nitrogen and inorganic phosphorus.