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Antiarthritic effect of lupeol acetate
Author(s) -
KweifioOkai G.,
Carroll Anthony R.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070227
Subject(s) - lupeol , petroleum ether , alkaline phosphatase , traditional medicine , pharmacognosy , ethyl acetate , chemistry , oral administration , medicine , pharmacology , biochemistry , biological activity , chromatography , enzyme , in vitro , extraction (chemistry)
Lupeol acetate isolated from the petroleum ether fraction of Alstonia boonei root barks was tested for its antiarthritic effect in CFA‐induced arthritic rats. Administered orally every 48 h (66 mg/kg body weight) from days 32 to 40 postadjuvant and assessed on day 60, Iupeol acetate returned the increase in spleen weight and the reduction in serum alkaline phosphatase to nonarthritic control values.