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Effects of the standardized Panax ginseng extract g115 on the D ‐glucose transport by Ehrlich ascites tumour cells
Author(s) -
Yamasaki K.,
Murakami C.,
Ohtani K.,
Kasai R.,
Kurokawa T.,
Ishibashi S.,
Soldati F.,
Stöckli M.,
Mulz D.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070222
Subject(s) - ginseng , ehrlich ascites , glucose transporter , glucose uptake , basal (medicine) , chemistry , biochemistry , microbiology and biotechnology , pharmacology , biology , medicine , endocrinology , tumor cells , cancer research , pathology , insulin , alternative medicine
The effect of standardized Panax ginseng extract (G115 Pharmaton) on D ‐glucose uptake by Ehrlich ascites tumour cells from mouse was examined. Measurements were carried out using [ 3 H]‐2‐deoxy‐ D ‐glucose, a non‐metabolizable glucose analogue. [ 3 H]‐2‐deoxy‐ D ‐glucose was transported from the medium to cells and phosphorylated but was neither further metabolized nor eliminated. Thus, the amount taken in the cells was a measure of D ‐glucose uptake. The results showed that G115 stimulated D ‐glucose transport and the maximum effect was obtained at a G115 concentration of 2.0 μg/mL representing an increase of about 35% above basal activity.
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