Oligo‐ and macrocyclic diterpenes in thymelaeaceae and euphorbiaceae occurring and utilized in yunnan (Southwest China) 4. Tigliane type diterpene esters (phorbol–12,13‐diesters) from  Wikstroemia canescens | Zendy

Dagang Wu | Zendy; Sorg B. | Zendy; Adolf W. | Zendy; Opferkuch H. J. | Zendy; Seip E. H. | Zendy; Hecker E. | Zendy

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Oligo‐ and macrocyclic diterpenes in thymelaeaceae and euphorbiaceae occurring and utilized in yunnan (Southwest China) 4. Tigliane type diterpene esters (phorbol–12,13‐diesters) from Wikstroemia canescens

Author(s) -

Dagang Wu,

Sorg B.,

Adolf W.,

Opferkuch H. J.,

Seip E. H.,

Hecker E.

Publication year - 1993

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2650070220

Subject(s) - thymelaeaceae , diterpene , euphorbiaceae , pharmacognosy , phorbol , phorbol ester , traditional medicine , terpenoid , chemistry , stereochemistry , medicine , biology , botany , protein kinase c , biological activity , biochemistry , in vitro , enzyme

From a methanol extract of the roots of Wikstroemia canescens (Wall) Meisen the hitherto unknown Wikstroemia factors C 1 and C 2 were isolated by means of a Craig distribution followed by TLC. They were identified as the tigliane type phorbol–12‐benzoate–13‐decanoate (C 2 ) and the corresponding–13‐3E, 5E‐decadienoate) (C 1 ). On the mouse ear Wikstroemia factor C 1 showed irritant activity comparable to that of the standard irritant phorbol ester 12‐O‐tetradecanoylphorbol–13‐acetate. Wikstroemia factor C 2 , not assayed for irritancy, may be expected to be about as active as C 1 .

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