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Oligo‐ and macrocyclic diterpenes in thymelaeaceae and euphorbiaceae occurring and utilized in yunnan (Southwest China) 4. Tigliane type diterpene esters (phorbol–12,13‐diesters) from Wikstroemia canescens
Author(s) -
Dagang Wu,
Sorg B.,
Adolf W.,
Opferkuch H. J.,
Seip E. H.,
Hecker E.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070220
Subject(s) - thymelaeaceae , diterpene , euphorbiaceae , pharmacognosy , phorbol , phorbol ester , traditional medicine , terpenoid , chemistry , stereochemistry , medicine , biology , botany , protein kinase c , biological activity , biochemistry , in vitro , enzyme
From a methanol extract of the roots of Wikstroemia canescens (Wall) Meisen the hitherto unknown Wikstroemia factors C 1 and C 2 were isolated by means of a Craig distribution followed by TLC. They were identified as the tigliane type phorbol–12‐benzoate–13‐decanoate (C 2 ) and the corresponding–13‐3E, 5E‐decadienoate) (C 1 ). On the mouse ear Wikstroemia factor C 1 showed irritant activity comparable to that of the standard irritant phorbol ester 12‐O‐tetradecanoylphorbol–13‐acetate. Wikstroemia factor C 2 , not assayed for irritancy, may be expected to be about as active as C 1 .