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Inhibitory effect of edible plant extracts on 12‐ O ‐tetradecanoylphorbol–13‐acetate‐induced ear oedema in mice
Author(s) -
Yasukawa K.,
Yamaguchi A.,
Arita J.,
Sakurai S.,
Ikeda A.,
Takido M.
Publication year - 1993
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2650070218
Subject(s) - 12 o tetradecanoylphorbol 13 acetate , pharmacognosy , traditional medicine , inhibitory postsynaptic potential , pharmacology , biology , chemistry , medicine , in vitro , biological activity , endocrinology , biochemistry , phorbol ester , signal transduction , protein kinase c
We report that spice, vegetable and fruit extracts inhibit 12– O ‐tetradecanoylphorbol–13‐acetate (TPA)‐induced ear oedema in mice. About 100 methanol extracts obtained from spices, vegetables and fruits were assayed and their inhibition ratios calculated. In general, the spice extracts were more effective inhibitors than vegetable and fruit extracts. The methanol extracts of hop, stevia, cinnamon, turmeric, mate, mint, New Zealand spinach, watercress, tomato and seedling of radish markedly inhibited the inflammatory activity induced by TPA in mice. Two active compounds, humulone and lupeol 3‐palmitate were separated from hop and stevia, respectively.